Publications at UConn

18. Liyange, C.D.; Ortiz-Garcia, J.J.; Struckmeier, A.; McCoy, C. L.; Kienzler, M.; Quardokus, R.C. A Scanning Tunneling Microscopy Study of the Photoisomerization of Diazocine. Phys. Chem. Lett .2024, 15, 4082. https://pubs.acs.org/doi/full/10.1021/acs.jpclett.4c00096

17. Liyange, C.D.; Ortiz-Garcia, J.J.; Struckmeier, A.; Kienzler, M.; Quardokus, R.C. Light-induced Photoswitching of 4-(Phenylazo)benzoic Acid on Au(111). ChemPhysChem, 2023, e202300160. https://doi.org/10.1002/cphc.202300160

16. Landra-Willm, A.; Karapurkar, A.; Duveau, A.; Chassot, A.A.; Esnault, L.; Callejo, G.; Bied, M.; Haefner, S.; Lesage, F.; Wdziekonski, B.; Baron, A.; Fossat, P.; Marsollier, L.; Gasull, X.; Boue;Grabot, E.; Kienzler, M.A.*; and Sandoz, G.* "A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals." Nat. Commun. 2023, 14, 1160. *corresponding authors. https://doi.org/10.1038/s41467-023-36806-4

15. Udasin, R.; Sil, A.; Zomot, E.; Achildiev Cohen, H.; Haj, J.; Engelmayer, N.; Lev, S.; Binshtok, A.M.; Shaked, Y.; Kienzler, M.A.* and Palty, R.* "Photopharmacological modulation of native CRAC channels using azoboronate photoswitches." Proc. Natl. Acad. Sci.USA. 2022, 119(13), p.e2118160119. *corresponding authors. https://doi.org/10.1073/pnas.2118160119

Publications pre-UConn

14. Carmi, I.; De Battista, M.; Maddalena, L.; Carroll, E.C.; Kienzler, M.A.; Berlin, S. “Holographic two-photon activation for synthetic optogenetics.” Nat. Protoc. 2019, 14, 864. https://doi.org/10.1038/s41596-018-0118-2

13. Tochitsky, I.*; Kienzler, M. A.*; Isacoff, E.; Kramer, R. H. “Restoring Vision to the Blind with Chemical Photoswitches.” Chem. Rev. 2018, 118, 10748. *Equal contributions. https://doi.org/10.1021/acs.chemrev.7b00723

12. Mourot, A.; Herold, C.; Kienzler, M. A.; Kramer, R. “Understanding and improving photo-control of ion channels in nociceptors with azobenzene photoswitches.”Br. J. Pharmacol. 2018, 175, 2296. https://doi.org/10.1111/bph.13923

11. Kienzler, M. A.*; Isacoff, E. Y.* “Precise modulation of neuronal activity with synthetic photoswitchable ligands” Curr. Opin. Neurobiol. 2017, 45, 202. *corresponding authors. https://doi.org/10.1016/j.conb.2017.05.021

10. Berlin, S.; Szobota, S.; Reiner, A.; Carroll, E.C.; Kienzler, M. A.; Guyon, A.; Xiao, T.; Trauner, D.; Isacoff, E.Y. “A Family of Photoswitchable NMDA Receptors.” eLife 2016, 5, E12040. https://doi.org/10.7554/eLife.12040

9. Morita, T.; McClain, S. P.; Batia, L. M.; Pellegrino, M.; Wilson, S. R.; Kienzler, M. A.; Lyman, K.; Olsen, A. S.; Wong, J. F.; Stucky, C. L.; Brem, B. L.; Bautista, D. M. “HTR7 Mediates Serotonergic Acute and Chronic Itch.” Neuron 2015, 87, 124. https://doi.org/10.1016/j.neuron.2015.05.044

8. Carroll, E. C.; Berlin, S.; Levitz, J.; Kienzler, M. A.; Yuan, Z.; Madsen, D.; Larsen, D. S.; Isacoff, E. Y.  “Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics.”  Proc. Natl. Acad. Sci.USA 2015, 112, E776. https://doi.org/10.1073/pnas.1416942112

7. Gaub, B. M.; Berry, M. H.; Holt, A. E.; Reiner, A.; Kienzler, M. A.; Dolgova, N.; Nikonov, S.; Aguirre, G. D.; Beltran, W. A.; Flannery, J. G.; Isacoff, E. Y.  “Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.”  Proc. Natl. Acad. Sci.USA 2014, 111, E5574. https://doi.org/10.1073/pnas.1414162111

6. Comoglio Y.; Levitz J.; Kienzler, M. A.; Lesage F.; Isacoff, E. Y.; Sandoz, G.  “Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.”  Proc. Natl. Acad. Sci.USA 2014, 111, 13547. https://doi.org/10.1073/pnas.1407160111

5. Kienzler, M. A.*; Reiner, A.*; Trautman, E.; Yoo, S.; Trauner, D.; Isacoff, E.  “A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor.”  J. Am. Chem. Soc. 2013, 135, 17683. *Equal contributions. https://doi.org/10.1021/ja408104w

4. Fehrentz, T.; Kuttruff, C.; Huber, F.; Kienzler, M. A.; Mayer, P; Trauner, D.  “Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers.”  Chem. Biochem. 2012, 13, 1746. https://doi.org/10.1002/cbic.201200216

3. Mourot, A.*; Kienzler, M. A.*; Banghart, M.; Ferhentz, T.; Huber, F.; Stein, M.; Kramer, R.; Trauner, D.  "Tuning Photochromic Ion Channel Blockers."  ACS Chem. Neurosci. 2011, 2, 536. *Equal contributions. https://doi.org/10.1021/cn200037p

2. Kienzler, M. A.; Suseno, S.; Trauner, D.  “Vinyl Quinones as Diels-Alder Dienes: Concise Synthesis of (–) -Halenaquinone.”  J. Am. Chem. Soc. 2008, 130, 8604. https://doi.org/10.1021/ja8035042

1. Rosa, C. P.; Kienzler, M.; Olson, B. S.; Liang, G.; Trauner, D.  “Total synthesis of smenochromene B through ring contraction.”  Tetrahedron 2007, 63, 6529. https://doi.org/10.1016/j.tet.2007.03.069